Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis.
Identifieur interne : 000312 ( Main/Exploration ); précédent : 000311; suivant : 000313Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis.
Auteurs : Hikaru Tamura [Japon] ; Tomoki Maekawa [Japon] ; Hisanori Domon [Japon] ; Takumi Hiyoshi [Japon] ; Daisuke Yonezawa [Japon] ; Kosuke Nagai [Japon] ; Akihito Ochiai [Japon] ; Masayuki Taniguchi [Japon] ; Koichi Tabeta [Japon] ; Takeyasu Maeda [Japon] ; Yutaka Terao [Japon]Source :
- Archives of oral biology [ 1879-1506 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antibactériens (administration et posologie), Antibactériens (pharmacologie), Antibactériens (usage thérapeutique), Cellules RAW 264.7 (MeSH), Cytokines (métabolisme), Endosperme (composition chimique), Extraits de plantes (pharmacologie), Extraits de plantes (usage thérapeutique), Gencive (effets des médicaments et des substances chimiques), Inflammation (MeSH), Ligature (MeSH), Microtomographie aux rayons X (méthodes), Modèles animaux de maladie humaine (MeSH), Molaire (MeSH), Mâle (MeSH), Oryza (composition chimique), Ostéoclastes (effets des médicaments et des substances chimiques), Parodontite (anatomopathologie), Parodontite (imagerie diagnostique), Parodontite (traitement médicamenteux), Peptides (administration et posologie), Peptides (antagonistes et inhibiteurs), Peptides (usage thérapeutique), Protéines végétales (administration et posologie), Protéines végétales (antagonistes et inhibiteurs), Protéines végétales (usage thérapeutique), Résorption alvéolaire (anatomopathologie), Résorption alvéolaire (imagerie diagnostique), Résorption alvéolaire (traitement médicamenteux), Résorption osseuse (anatomopathologie), Résorption osseuse (imagerie diagnostique), Résorption osseuse (traitement médicamenteux), Souris (MeSH), Souris de lignée BALB C (MeSH), Survie cellulaire (effets des médicaments et des substances chimiques).
- MESH :
- administration et posologie : Antibactériens, Peptides, Protéines végétales.
- anatomopathologie : Parodontite, Résorption alvéolaire, Résorption osseuse.
- antagonistes et inhibiteurs : Peptides, Protéines végétales.
- composition chimique : Endosperme, Oryza.
- effets des médicaments et des substances chimiques : Gencive, Ostéoclastes, Survie cellulaire.
- imagerie diagnostique : Parodontite, Résorption alvéolaire, Résorption osseuse.
- métabolisme : Cytokines.
- méthodes : Microtomographie aux rayons X.
- pharmacologie : Antibactériens, Extraits de plantes.
- traitement médicamenteux : Parodontite, Résorption alvéolaire, Résorption osseuse.
- usage thérapeutique : Antibactériens, Extraits de plantes, Peptides, Protéines végétales.
- Animaux, Cellules RAW 264.7, Inflammation, Ligature, Modèles animaux de maladie humaine, Molaire, Mâle, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Alveolar Bone Loss (diagnostic imaging), Alveolar Bone Loss (drug therapy), Alveolar Bone Loss (pathology), Animals (MeSH), Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (pharmacology), Anti-Bacterial Agents (therapeutic use), Bone Resorption (diagnostic imaging), Bone Resorption (drug therapy), Bone Resorption (pathology), Cell Survival (drug effects), Cytokines (metabolism), Disease Models, Animal (MeSH), Endosperm (chemistry), Gingiva (drug effects), Inflammation (MeSH), Ligation (MeSH), Male (MeSH), Mice (MeSH), Mice, Inbred BALB C (MeSH), Molar (MeSH), Oryza (chemistry), Osteoclasts (drug effects), Peptides (administration & dosage), Peptides (antagonists & inhibitors), Peptides (therapeutic use), Periodontitis (diagnostic imaging), Periodontitis (drug therapy), Periodontitis (pathology), Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Plant Proteins (administration & dosage), Plant Proteins (antagonists & inhibitors), Plant Proteins (therapeutic use), RAW 264.7 Cells (MeSH), X-Ray Microtomography (methods).
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Peptides, Plant Proteins.
- chemical , antagonists & inhibitors : Peptides, Plant Proteins.
- chemistry : Endosperm, Oryza.
- diagnostic imaging : Alveolar Bone Loss, Bone Resorption, Periodontitis.
- drug effects : Cell Survival, Gingiva, Osteoclasts.
- drug therapy : Alveolar Bone Loss, Bone Resorption, Periodontitis.
- chemical , metabolism : Cytokines.
- methods : X-Ray Microtomography.
- pathology : Alveolar Bone Loss, Bone Resorption, Periodontitis.
- chemical , pharmacology : Anti-Bacterial Agents, Plant Extracts.
- chemical , therapeutic use : Anti-Bacterial Agents, Peptides, Plant Extracts, Plant Proteins.
- Animals, Disease Models, Animal, Inflammation, Ligation, Male, Mice, Mice, Inbred BALB C, Molar, RAW 264.7 Cells.
Abstract
OBJECTIVE
Food-derived peptides have been reported to exhibit antibacterial activity against periodontal pathogenic bacteria. However, no effect has been shown on inflammation and bone resorption in periodontal pathology. The overall objective of the current study was to investigate how rice peptides influence biological defense mechanisms against periodontitis-induced inflammatory bone loss, and identify their novel functions as a potential anti-inflammatory drug.
DESIGN
The expression of inflammatory and osteoclast-related molecules was examined in mouse macrophage-derived RAW 264.7 cell cultures using qPCR. Subsequently, the effect of these peptides on inflammatory bone loss in mouse periodontitis was examined using a mouse model of tooth ligation. Briefly, periodontal bone loss was induced for 7 days in mice by ligating the maxillary second molar and leaving the contralateral tooth un-ligated (baseline control). The mice were microinjected daily with the peptide in the gingiva until the day before euthanization. One week after the ligation, TRAP-positive multinucleated cells (MNCs) were enumerated from five random coronal sections of the ligated sites in each mouse.
RESULTS
Rice peptides REP9 and REP11 significantly inhibited transcription activity of inflammatory and osteoclast-related molecules. Local treatment with the rice peptides, in mice subjected to ligature-induced periodontitis, inhibited inflammatory bone loss, explaining the decreased numbers of osteoclasts in bone tissue sections.
CONCLUSION
Therefore, these data suggested that the rice peptides possess a protective effect against periodontitis.
DOI: 10.1016/j.archoralbio.2018.11.021
PubMed: 30485826
Affiliations:
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Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. Electronic address: terao@dent.niigata-u.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30485826</idno><idno type="pmid">30485826</idno><idno type="doi">10.1016/j.archoralbio.2018.11.021</idno><idno type="wicri:Area/Main/Corpus">000576</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000576</idno><idno type="wicri:Area/Main/Curation">000576</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000576</idno><idno type="wicri:Area/Main/Exploration">000576</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis.</title><author><name sortKey="Tamura, Hikaru" sort="Tamura, Hikaru" uniqKey="Tamura H" first="Hikaru" last="Tamura">Hikaru Tamura</name><affiliation wicri:level="1"><nlm:affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Maekawa, Tomoki" sort="Maekawa, Tomoki" uniqKey="Maekawa T" first="Tomoki" last="Maekawa">Tomoki Maekawa</name><affiliation wicri:level="1"><nlm:affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Domon, Hisanori" sort="Domon, Hisanori" uniqKey="Domon H" first="Hisanori" last="Domon">Hisanori Domon</name><affiliation wicri:level="1"><nlm:affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Hiyoshi, Takumi" sort="Hiyoshi, Takumi" uniqKey="Hiyoshi T" first="Takumi" last="Hiyoshi">Takumi Hiyoshi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Yonezawa, Daisuke" sort="Yonezawa, Daisuke" uniqKey="Yonezawa D" first="Daisuke" last="Yonezawa">Daisuke Yonezawa</name><affiliation wicri:level="1"><nlm:affiliation>Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Oral Science for Health Promotion, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Oral Science for Health Promotion, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Nagai, Kosuke" sort="Nagai, Kosuke" uniqKey="Nagai K" first="Kosuke" last="Nagai">Kosuke Nagai</name><affiliation wicri:level="1"><nlm:affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Ochiai, Akihito" sort="Ochiai, Akihito" uniqKey="Ochiai A" first="Akihito" last="Ochiai">Akihito Ochiai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Taniguchi, Masayuki" sort="Taniguchi, Masayuki" uniqKey="Taniguchi M" first="Masayuki" last="Taniguchi">Masayuki Taniguchi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Tabeta, Koichi" sort="Tabeta, Koichi" uniqKey="Tabeta K" first="Koichi" last="Tabeta">Koichi Tabeta</name><affiliation wicri:level="1"><nlm:affiliation>Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Maeda, Takeyasu" sort="Maeda, Takeyasu" uniqKey="Maeda T" first="Takeyasu" last="Maeda">Takeyasu Maeda</name><affiliation wicri:level="1"><nlm:affiliation>Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author><author><name sortKey="Terao, Yutaka" sort="Terao, Yutaka" uniqKey="Terao Y" first="Yutaka" last="Terao">Yutaka Terao</name><affiliation wicri:level="1"><nlm:affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. Electronic address: terao@dent.niigata-u.ac.jp.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata</wicri:regionArea><wicri:noRegion>Niigata</wicri:noRegion></affiliation></author></analytic><series><title level="j">Archives of oral biology</title><idno type="eISSN">1879-1506</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Bone Loss (diagnostic imaging)</term><term>Alveolar Bone Loss (drug therapy)</term><term>Alveolar Bone Loss (pathology)</term><term>Animals (MeSH)</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Bone Resorption (diagnostic imaging)</term><term>Bone Resorption (drug therapy)</term><term>Bone Resorption (pathology)</term><term>Cell Survival (drug effects)</term><term>Cytokines (metabolism)</term><term>Disease Models, Animal (MeSH)</term><term>Endosperm (chemistry)</term><term>Gingiva (drug effects)</term><term>Inflammation (MeSH)</term><term>Ligation (MeSH)</term><term>Male (MeSH)</term><term>Mice (MeSH)</term><term>Mice, Inbred BALB C (MeSH)</term><term>Molar (MeSH)</term><term>Oryza (chemistry)</term><term>Osteoclasts (drug effects)</term><term>Peptides (administration & dosage)</term><term>Peptides (antagonists & inhibitors)</term><term>Peptides (therapeutic use)</term><term>Periodontitis (diagnostic imaging)</term><term>Periodontitis (drug therapy)</term><term>Periodontitis (pathology)</term><term>Plant Extracts (pharmacology)</term><term>Plant Extracts (therapeutic use)</term><term>Plant Proteins (administration & dosage)</term><term>Plant Proteins (antagonists & inhibitors)</term><term>Plant Proteins (therapeutic use)</term><term>RAW 264.7 Cells (MeSH)</term><term>X-Ray Microtomography (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Antibactériens (administration et posologie)</term><term>Antibactériens (pharmacologie)</term><term>Antibactériens (usage thérapeutique)</term><term>Cellules RAW 264.7 (MeSH)</term><term>Cytokines (métabolisme)</term><term>Endosperme (composition chimique)</term><term>Extraits de plantes (pharmacologie)</term><term>Extraits de plantes (usage thérapeutique)</term><term>Gencive (effets des médicaments et des substances chimiques)</term><term>Inflammation (MeSH)</term><term>Ligature (MeSH)</term><term>Microtomographie aux rayons X (méthodes)</term><term>Modèles animaux de maladie humaine (MeSH)</term><term>Molaire (MeSH)</term><term>Mâle (MeSH)</term><term>Oryza (composition chimique)</term><term>Ostéoclastes (effets des médicaments et des substances chimiques)</term><term>Parodontite (anatomopathologie)</term><term>Parodontite (imagerie diagnostique)</term><term>Parodontite (traitement médicamenteux)</term><term>Peptides (administration et posologie)</term><term>Peptides (antagonistes et inhibiteurs)</term><term>Peptides (usage thérapeutique)</term><term>Protéines végétales (administration et posologie)</term><term>Protéines végétales (antagonistes et inhibiteurs)</term><term>Protéines végétales (usage thérapeutique)</term><term>Résorption alvéolaire (anatomopathologie)</term><term>Résorption alvéolaire (imagerie diagnostique)</term><term>Résorption alvéolaire (traitement médicamenteux)</term><term>Résorption osseuse (anatomopathologie)</term><term>Résorption osseuse (imagerie diagnostique)</term><term>Résorption osseuse (traitement médicamenteux)</term><term>Souris (MeSH)</term><term>Souris de lignée BALB C (MeSH)</term><term>Survie cellulaire (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Peptides</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Peptides</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antibactériens</term><term>Peptides</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Parodontite</term><term>Résorption alvéolaire</term><term>Résorption osseuse</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Peptides</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Endosperm</term><term>Oryza</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Endosperme</term><term>Oryza</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alveolar Bone Loss</term><term>Bone Resorption</term><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Gingiva</term><term>Osteoclasts</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Alveolar Bone Loss</term><term>Bone Resorption</term><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Gencive</term><term>Ostéoclastes</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Parodontite</term><term>Résorption alvéolaire</term><term>Résorption osseuse</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>X-Ray Microtomography</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Microtomographie aux rayons X</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Bone Loss</term><term>Bone Resorption</term><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Peptides</term><term>Plant Extracts</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Parodontite</term><term>Résorption alvéolaire</term><term>Résorption osseuse</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term><term>Extraits de plantes</term><term>Peptides</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Inflammation</term><term>Ligation</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Molar</term><term>RAW 264.7 Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules RAW 264.7</term><term>Inflammation</term><term>Ligature</term><term>Modèles animaux de maladie humaine</term><term>Molaire</term><term>Mâle</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Food-derived peptides have been reported to exhibit antibacterial activity against periodontal pathogenic bacteria. However, no effect has been shown on inflammation and bone resorption in periodontal pathology. The overall objective of the current study was to investigate how rice peptides influence biological defense mechanisms against periodontitis-induced inflammatory bone loss, and identify their novel functions as a potential anti-inflammatory drug.</p></div><div type="abstract" xml:lang="en"><p><b>DESIGN</b></p><p>The expression of inflammatory and osteoclast-related molecules was examined in mouse macrophage-derived RAW 264.7 cell cultures using qPCR. Subsequently, the effect of these peptides on inflammatory bone loss in mouse periodontitis was examined using a mouse model of tooth ligation. Briefly, periodontal bone loss was induced for 7 days in mice by ligating the maxillary second molar and leaving the contralateral tooth un-ligated (baseline control). The mice were microinjected daily with the peptide in the gingiva until the day before euthanization. One week after the ligation, TRAP-positive multinucleated cells (MNCs) were enumerated from five random coronal sections of the ligated sites in each mouse.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Rice peptides REP9 and REP11 significantly inhibited transcription activity of inflammatory and osteoclast-related molecules. Local treatment with the rice peptides, in mice subjected to ligature-induced periodontitis, inhibited inflammatory bone loss, explaining the decreased numbers of osteoclasts in bone tissue sections.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Therefore, these data suggested that the rice peptides possess a protective effect against periodontitis.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30485826</PMID><DateCompleted><Year>2019</Year><Month>06</Month><Day>21</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1506</ISSN><JournalIssue CitedMedium="Internet"><Volume>98</Volume><PubDate><Year>2019</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Archives of oral biology</Title><ISOAbbreviation>Arch Oral Biol</ISOAbbreviation></Journal><ArticleTitle>Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis.</ArticleTitle><Pagination><MedlinePgn>132-139</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0003-9969(18)30376-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.archoralbio.2018.11.021</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Food-derived peptides have been reported to exhibit antibacterial activity against periodontal pathogenic bacteria. However, no effect has been shown on inflammation and bone resorption in periodontal pathology. The overall objective of the current study was to investigate how rice peptides influence biological defense mechanisms against periodontitis-induced inflammatory bone loss, and identify their novel functions as a potential anti-inflammatory drug.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">The expression of inflammatory and osteoclast-related molecules was examined in mouse macrophage-derived RAW 264.7 cell cultures using qPCR. Subsequently, the effect of these peptides on inflammatory bone loss in mouse periodontitis was examined using a mouse model of tooth ligation. Briefly, periodontal bone loss was induced for 7 days in mice by ligating the maxillary second molar and leaving the contralateral tooth un-ligated (baseline control). The mice were microinjected daily with the peptide in the gingiva until the day before euthanization. One week after the ligation, TRAP-positive multinucleated cells (MNCs) were enumerated from five random coronal sections of the ligated sites in each mouse.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Rice peptides REP9 and REP11 significantly inhibited transcription activity of inflammatory and osteoclast-related molecules. Local treatment with the rice peptides, in mice subjected to ligature-induced periodontitis, inhibited inflammatory bone loss, explaining the decreased numbers of osteoclasts in bone tissue sections.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Therefore, these data suggested that the rice peptides possess a protective effect against periodontitis.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tamura</LastName><ForeName>Hikaru</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maekawa</LastName><ForeName>Tomoki</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domon</LastName><ForeName>Hisanori</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hiyoshi</LastName><ForeName>Takumi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yonezawa</LastName><ForeName>Daisuke</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Division of Oral Science for Health Promotion, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nagai</LastName><ForeName>Kosuke</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ochiai</LastName><ForeName>Akihito</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taniguchi</LastName><ForeName>Masayuki</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Materials Science and Technology, Graduate School of Science and Technology, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tabeta</LastName><ForeName>Koichi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maeda</LastName><ForeName>Takeyasu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terao</LastName><ForeName>Yutaka</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. Electronic address: terao@dent.niigata-u.ac.jp.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>11</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Arch Oral Biol</MedlineTA><NlmUniqueID>0116711</NlmUniqueID><ISSNLinking>0003-9969</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016301" MajorTopicYN="N">Alveolar Bone Loss</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001862" MajorTopicYN="N">Bone Resorption</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056625" MajorTopicYN="N">Endosperm</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008026" MajorTopicYN="N">Ligation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008963" MajorTopicYN="N">Molar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012275" MajorTopicYN="N">Oryza</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010010" MajorTopicYN="N">Osteoclasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000067996" MajorTopicYN="N">RAW 264.7 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055114" MajorTopicYN="N">X-Ray Microtomography</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Bone loss</Keyword><Keyword MajorTopicYN="N">Food peptide</Keyword><Keyword MajorTopicYN="N">Inflammation</Keyword><Keyword MajorTopicYN="N">Osteoclastogenesis</Keyword><Keyword MajorTopicYN="N">Periodontitis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>07</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>11</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>11</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>11</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30485826</ArticleId><ArticleId IdType="pii">S0003-9969(18)30376-5</ArticleId><ArticleId IdType="doi">10.1016/j.archoralbio.2018.11.021</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Tamura, Hikaru" sort="Tamura, Hikaru" uniqKey="Tamura H" first="Hikaru" last="Tamura">Hikaru Tamura</name></noRegion><name sortKey="Domon, Hisanori" sort="Domon, Hisanori" uniqKey="Domon H" first="Hisanori" last="Domon">Hisanori Domon</name><name sortKey="Hiyoshi, Takumi" sort="Hiyoshi, Takumi" uniqKey="Hiyoshi T" first="Takumi" last="Hiyoshi">Takumi Hiyoshi</name><name sortKey="Maeda, Takeyasu" sort="Maeda, Takeyasu" uniqKey="Maeda T" first="Takeyasu" last="Maeda">Takeyasu Maeda</name><name sortKey="Maekawa, Tomoki" sort="Maekawa, Tomoki" uniqKey="Maekawa T" first="Tomoki" last="Maekawa">Tomoki Maekawa</name><name sortKey="Nagai, Kosuke" sort="Nagai, Kosuke" uniqKey="Nagai K" first="Kosuke" last="Nagai">Kosuke Nagai</name><name sortKey="Ochiai, Akihito" sort="Ochiai, Akihito" uniqKey="Ochiai A" first="Akihito" last="Ochiai">Akihito Ochiai</name><name sortKey="Tabeta, Koichi" sort="Tabeta, Koichi" uniqKey="Tabeta K" first="Koichi" last="Tabeta">Koichi Tabeta</name><name sortKey="Taniguchi, Masayuki" sort="Taniguchi, Masayuki" uniqKey="Taniguchi M" first="Masayuki" last="Taniguchi">Masayuki Taniguchi</name><name sortKey="Terao, Yutaka" sort="Terao, Yutaka" uniqKey="Terao Y" first="Yutaka" last="Terao">Yutaka Terao</name><name sortKey="Yonezawa, Daisuke" sort="Yonezawa, Daisuke" uniqKey="Yonezawa D" first="Daisuke" last="Yonezawa">Daisuke Yonezawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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